Basic Information
VIS ID
TVIS44023739
Fusion event
HTLV-1-NTRK3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
88491322/87948091 (Hg38)
End
88491322/87948091 (Hg38)
Orient
+
Location type
Intronic
Target gene
NTRK3
miRNAs that regulate target gene
hsa-mir-765 ; hsa-mir-485-3p ; hsa-mir-128-3p ; hsa-mir-9-5p ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-617 ; hsa-mir-345-5p ; hsa-mir-384 ; hsa-mir-330-3p ; hsa-mir-198 ; hsa-mir-625-5p ; hsa-mir-509-3p ; hsa-mir-151a-3p ; hsa-mir-185-5p ; hsa-mir-768-5p ; hsa-mir-615-3p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-1277-5p ; hsa-mir-410-3p ; hsa-mir-4776-3p ; hsa-mir-192-3p
Nearest miRNA
hsa-mir-10393/Upstream/1823; hsa-mir-1179/Downstream/660016;
Nearest TSS
ENST00000557528/Upstream/7356; ENST00000569588/Downstream/30712;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/2107207, chr15-CpG: 36/Downstream/307332
Nearest cancer related gene
NTRK3(OG, No orient, 0)
Upstream sequence
AAATTTCTGCCAGCCCTCAAAGAACTGCCCTCACACTTTCTCCTGGCCTCCTGGCTGGGTCTCACCTCACGCCTTCTATGAATGGCAAGCAAGAGGAGCT
Downstream sequence
AATTGCATAAGGTATTGCATAAGAGCATAGCCAGACAAACATGTGCCCTGGCCAGCTACAGGCCCTTTGTAGGGGTCTCCAGCCAACCCAGTCAGTTCTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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