Basic Information
VIS ID
TVIS44023757
Fusion event
HTLV-1-CLEC16A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.13
Reference genome
GRCh37/hg19
Start
11103794/11009937 (Hg38)
End
11103794/11009937 (Hg38)
Orient
-
Location type
Intronic
Target gene
CLEC16A
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-331-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1225/Upstream/5377371; hsa-mir-11401/Downstream/296503;
Nearest TSS
ENST00000527434/Upstream/37456; ENST00000487189/Downstream/14216;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/65031, chr16-CpG: 28/Downstream/164098
Upstream sequence
TAGATGGTACAGGGAGAGCCTTAAAGAATATGGTggccaggcgcagtggctcacacctgtaatcccagcacttcgggaggccaacacaagaggatcacct
Downstream sequence
gagcccagaagttcaagaccagccaggcaacatagggagacccctgtctgtacaaaaaataaaaaactagccagtcacagcggtgtgtgcctgtagtccc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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