Basic Information
VIS ID
TVIS44023767
Fusion event
HTLV-1-COG7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
23411924/23400603 (Hg38)
End
23411924/23400603 (Hg38)
Orient
-
Location type
Intronic
Target gene
COG7
miRNAs that regulate target gene
hsa-mir-6807-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-6504-3p ; hsa-mir-4438
Nearest miRNA
hsa-mir-1225/Upstream/1894468; hsa-mir-11401/Downstream/802513;
Nearest TSS
ENST00000527434/Upstream/5657; ENST00000565747/Downstream/16690;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/97978, chr16-CpG: 25/Downstream/7509
Upstream sequence
ATCCATCCCAGGGACTGCAGCCTGGAGGCCCCAGGAAAGGCCTCAAAGGGGAGGCAGGAGGAGCAGCCTCAAAACATGAACAGGCAGAGGAGAGAGGGAA
Downstream sequence
AGAACAGCTGGAGTGGGAAAGAAGTTTGGAAGAAGCGCAAGACAGAGTGGCTTGAAATAGGAGGGTGCTTAAAAAGCAGCAGATggctggctgcggtggc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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