Basic Information
VIS ID
TVIS44023787
Fusion event
HTLV-1-ADCY7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
50288185/50254274 (Hg38)
End
50288185/50254274 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADCY7
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-4776-3p ; hsa-mir-744-3p ; hsa-mir-874-3p ; hsa-mir-3157-3p ; hsa-mir-4659a-5p ; hsa-mir-4659b-5p ; hsa-mir-5590-5p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-6886-3p ; hsa-mir-938 ; hsa-mir-338-3p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-302f ; hsa-mir-634
Nearest miRNA
hsa-mir-1225/Upstream/16090601; hsa-mir-11401/Downstream/38342;
Nearest TSS
ENST00000527434/Upstream/8126; ENST00000568933/Downstream/12242;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/7580, chr16-CpG: 98/Downstream/114054
Nearby gene
ADCY7(+12266) ;
Upstream sequence
TTGACGTTTCATTATGAACAAGCCAACAGACACAGCAGCAGACAGGGCAGCCCACCAGCACGCCACTCCACGCACCCCTGCCTCCGCTTCCGCAGGCTCC
Downstream sequence
AGCCCATGGCCTCTGGGAGCTGCCTCTCCTCCCACACACAGCCCCCTCCAGGCACCCTGTCACTTCATCTGTGAGAATGGTAGTCTATGTTACTAAAAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate