Basic Information
VIS ID
TVIS44023797
Fusion event
HTLV-1-SLC12A3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q13
Reference genome
GRCh37/hg19
Start
56938759/56904847 (Hg38)
End
56938759/56904847 (Hg38)
Orient
+
Location type
Intronic
Target gene
SLC12A3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1273e ; hsa-mir-4524a-3p ; hsa-mir-4329 ; hsa-mir-5680 ; hsa-mir-2355-3p ; hsa-mir-629-3p ; hsa-mir-676-3p ; hsa-mir-6867-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-623 ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-136-5p ; hsa-mir-6780b-3p ; hsa-mir-4780
Nearest miRNA
hsa-mir-1225/Upstream/494; hsa-mir-11401/Downstream/867442;
Nearest TSS
ENST00000527434/Upstream/2625; ENST00000563352/Downstream/2179;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/174282, chr16-CpG: 80/Downstream/26975
Upstream sequence
AAATTCCACTTGGCAAAGAGGGAACCCAGCTCTTTCAAGAGGGACATCAACTCCTGGTTGTTCAGGAATTACTTGGCCCTCCTTGGCTATCGGCCATTCC
Downstream sequence
CAGCTGATGTTGGTTCCAAGCCTGAGCAACAGAAACAGAGGCCTGTCCTAGCCCTGGCTGTTCCTACTGGACCCACGTCCAGTTCTGAGCCACCCCTGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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