Basic Information
VIS ID
TVIS44023798
Fusion event
HTLV-1-RBFOX1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
5790957/5740956 (Hg38)
End
5790957/5740956 (Hg38)
Orient
-
Location type
Intronic
Target gene
RBFOX1
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-let-7b-5p ; hsa-mir-3157-5p ; hsa-mir-153-5p ; hsa-mir-935 ; hsa-mir-4691-3p ; hsa-mir-1305 ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-498 ; hsa-mir-4753-3p ; hsa-mir-627-3p ; hsa-mir-6832-3p ; hsa-mir-562
Nearest miRNA
hsa-mir-1225/Upstream/108390; hsa-mir-11401/Downstream/5565484;
Nearest TSS
ENST00000527434/Upstream/124760; ENST00000548749/Downstream/278138;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/500571, chr16-CpG: 127/Downstream/277957
Nearby gene
MIR8065(No orient, 108390)
Upstream sequence
tgcccgtctggacagatgaccatggtggcagggaacggaaGTCACCGTTTGTTGTGTACTACCCTGGAGTGAGGACTGGAGTCATGATGAGTTGGAGTGG
Downstream sequence
GATCATGAGGGATGGTCCTTAAAATAGGTTAAAGGAGGCAGGTGGTAAAAAATTAAAAAATGTCTATGTCTTggtactattatcacctctgttttgtaga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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