Basic Information
VIS ID
TVIS44023799
Fusion event
HTLV-1-CNOT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q21
Reference genome
GRCh37/hg19
Start
58656398/58622494 (Hg38)
End
58656398/58622494 (Hg38)
Orient
-
Location type
Intronic
Target gene
CNOT1
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-mir-93-3p ; hsa-mir-766-3p ; hsa-mir-454-3p ; hsa-mir-421 ; hsa-mir-615-3p ; hsa-mir-193b-3p ; hsa-mir-423-3p ; hsa-mir-130b-3p ; hsa-mir-128-3p ; hsa-mir-221-3p ; hsa-mir-92a-3p ; hsa-mir-23a-3p ; hsa-let-7b-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1225/Upstream/850142; hsa-mir-11401/Downstream/8579827;
Nearest TSS
ENST00000527434/Upstream/23157; ENST00000565722/Downstream/2292;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/106159, chr16-CpG: 80/Downstream/6577
Upstream sequence
gataatacaggaaacctctgtactttctcatcaattttactgtgatcccaaaactgctctaaaaaataaaatcaattaagaaaAAAACGCAAAACCTAGA
Downstream sequence
AGCTATAAATCTAAGGGAACAAACGTTTAATTATCTGACTCGGAAACTGCTGAGTTCTGAATATAAAGCTTAAGAATATTATAggctcacgcctataatc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate