Basic Information
VIS ID
TVIS44023810
Fusion event
HTLV-1-RBFOX1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
7528922/7478920 (Hg38)
End
7528922/7478920 (Hg38)
Orient
+
Location type
Intronic
Target gene
RBFOX1
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-let-7b-5p ; hsa-mir-3157-5p ; hsa-mir-153-5p ; hsa-mir-935 ; hsa-mir-4691-3p ; hsa-mir-1305 ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-498 ; hsa-mir-4753-3p ; hsa-mir-627-3p ; hsa-mir-6832-3p ; hsa-mir-562
Nearest miRNA
hsa-mir-1225/Upstream/1846354; hsa-mir-11401/Downstream/3827520;
Nearest TSS
ENST00000527434/Upstream/56142; ENST00000570626/Downstream/31202;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/174313, chr16-CpG: 22/Downstream/39273
Upstream sequence
CTGAGGATGTAGAAAACCTCCTTTGCTTGAGTCGAGCGCCTTGAAATAGCTCTGTTGCATCTTGAACGGGGCTAGTTTGTTAATTCGATGAGTAAAGGGG
Downstream sequence
AGAGTACCATCATTTCGTTTGTTCCCGTGCGGACCGAACACGGTATTAGCCTCTCTGCAGATACAATCTCACTTAGACGTACCAGCCACTGTGAGAGTGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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