Basic Information
VIS ID
TVIS44023823
Fusion event
HTLV-1-CDH13 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
82954465/82920860 (Hg38)
End
82954465/82920860 (Hg38)
Orient
+
Location type
Intronic
Target gene
CDH13
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-181a-5p ; hsa-mir-4464 ; hsa-mir-4307 ; hsa-mir-7152-5p ; hsa-mir-3074-5p ; hsa-mir-31-3p ; hsa-mir-367-5p ; hsa-mir-1266-3p
Nearest miRNA
hsa-mir-1225/Upstream/231841; hsa-mir-11401/Downstream/587486;
Nearest TSS
ENST00000527434/Upstream/293821; ENST00000569454/Downstream/5098;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/292652, chr16-CpG: 67/Downstream/886947
Nearest cancer related gene
CDH13(TSG, No orient, 0)
Upstream sequence
cagacagaagggttaagaatggacatcattgccttgtttctgatgttaagtggaaagtatttcatctattaaacatttataccactaagtatgatgctcc
Downstream sequence
ctgaaggcttttcagatgtgctctttatcatattgagtgagccccattcaatttcaaatttgttaaaaatcttttatcatgaataagtgttagattttat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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