Basic Information
VIS ID
TVIS44023847
Fusion event
HTLV-1-NLK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
26462637/28135611 (Hg38)
End
26462637/28135611 (Hg38)
Orient
+
Location type
Intronic
Target gene
NLK
miRNAs that regulate target gene
hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-92b-3p ; hsa-mir-23a-3p ; hsa-mir-199b-5p ; hsa-mir-101-3p ; hsa-mir-3682-5p ; hsa-mir-513a-5p ; hsa-mir-545-3p ; hsa-mir-3120-3p ; hsa-mir-5692a ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-1277-5p ; hsa-mir-3121-3p ; hsa-mir-548c-3p ; hsa-mir-574-5p ; hsa-mir-6818-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-6867-5p ; hsa-mir-1304-3p ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-1285-5p ; hsa-mir-216a-5p ; hsa-mir-6802-5p ; hsa-mir-6800-5p ; hsa-mir-6822-3p ; hsa-mir-3622b-5p ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-6741-3p ; hsa-mir-135a-3p ; hsa-mir-6865-5p ; hsa-mir-6815-5p ; hsa-mir-3158-3p ; hsa-mir-4446-3p ; hsa-mir-5088-5p ; hsa-mir-944 ; hsa-mir-409-3p
Nearest miRNA
hsa-mir-1180/Upstream/841615; hsa-mir-10226/Downstream/225043;
Nearest TSS
ENST00000595228/Upstream/92581; ENST00000584188/Downstream/35622;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/93504, chr17-CpG: 74/Downstream/91607
Upstream sequence
aggtatactaagatactattgtcaggtggatattgcagtggcccagaggttatttcctagaagtcaggggccagtcttgaagactttcggaatgtgcagg
Downstream sequence
gtttggacagcccaggtctgctgagttaaccctttactgcacaTAGGCCATATGTGAAGAAAGAATGTTTCCATGTAAGATAATTGGTGAATGTGGATAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate