Basic Information
VIS ID
TVIS44023850
Fusion event
HTLV-1-SSH2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
28029661/29702643 (Hg38)
End
28029661/29702643 (Hg38)
Orient
+
Location type
Intronic
Target gene
SSH2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-130b-5p ; hsa-mir-222-3p ; hsa-mir-20a-5p ; hsa-mir-155-5p ; hsa-mir-106b-5p ; hsa-mir-526b-5p ; hsa-mir-4445-5p ; hsa-mir-6766-3p ; hsa-mir-4782-3p ; hsa-mir-219a-5p ; hsa-mir-508-3p ; hsa-mir-574-5p ; hsa-mir-4693-3p ; hsa-mir-5584-3p ; hsa-mir-4311 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-196a-3p ; hsa-mir-6860 ; hsa-mir-661 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-6849-3p ; hsa-mir-759 ; hsa-mir-5586-3p ; hsa-mir-508-5p ; hsa-mir-4797-5p ; hsa-mir-623 ; hsa-mir-6780b-3p ; hsa-mir-4780 ; hsa-mir-26a-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-93-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-1180/Upstream/311913; hsa-mir-10226/Downstream/414436;
Nearest TSS
ENST00000595228/Upstream/63016; ENST00000577846/Downstream/58460;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/79384, chr17-CpG: 73/Downstream/58366
Upstream sequence
actcaggaggctgaggcaagaggatcgcttgaacccaggaggtggaggttgcagtgatctgggatcgtgccactgcactccaccctgggtgacacagcga
Downstream sequence
aactccatctcaaaaaaacaaaacaaaacaaaacaaCCCCAATCTTAACTGAGAAGTTCCATATAACTTCATTATTTTGGTACCGTCTTAttattattcc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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