Basic Information
VIS ID
TVIS44023851
Fusion event
HTLV-1-RHOT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
30549512/32222493 (Hg38)
End
30549512/32222493 (Hg38)
Orient
+
Location type
Intronic
Target gene
RHOT1
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-335-5p ; hsa-mir-877-3p ; hsa-mir-139-5p
Nearest miRNA
hsa-mir-1180/Upstream/646972; hsa-mir-10226/Downstream/127616;
Nearest TSS
ENST00000595228/Upstream/11377; ENST00000582967/Downstream/43683;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/79570, chr17-CpG: 197/Downstream/43082
Upstream sequence
ACTTATGGTTACTACGTGTTGTCAGGTACTGCTTATGGTATTGGTTTAAAGGACTTGGTATTTCAGATGCACCAAGACCAGCCTCATAGGGATGTTTAGA
Downstream sequence
GAATGTATATAACAGCTTTAGGTTTCCTTGTCTGGAGTGGGTGTGTGTGTGTGTTTGTTAACAGAGTACATACAGATAGATTTTTTTTTTAAGTTTGGCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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