Basic Information
VIS ID
TVIS44023855
Fusion event
HTLV-1-PCGF2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q12
Reference genome
GRCh37/hg19
Start
36898764/38742511 (Hg38)
End
36898764/38742511 (Hg38)
Orient
+
Location type
Intronic
Target gene
PCGF2
miRNAs that regulate target gene
hsa-mir-33a-5p ; hsa-mir-296-3p ; hsa-mir-548t-3p ; hsa-mir-548aa ; hsa-mir-548ap-3p ; hsa-mir-1277-5p ; hsa-mir-493-5p ; hsa-mir-190a-3p ; hsa-mir-340-5p ; hsa-mir-5011-5p ; hsa-mir-3163 ; hsa-mir-5580-3p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-384 ; hsa-mir-3685 ; hsa-mir-337-3p ; hsa-mir-202-5p ; hsa-mir-21-5p
Nearest miRNA
hsa-mir-1180/Upstream/22763; hsa-mir-10226/Downstream/83327;
Nearest TSS
ENST00000595228/Upstream/6915; ENST00000610658/Downstream/4117;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/12106, chr17-CpG: 209/Downstream/5107
Nearest cancer related gene
PCGF2(TSG, No orient, 0)
Upstream sequence
CCAACAGAGGCTCAGGGAACCTGGCCAGAGACCGAAAGAGATGCAGAGACACAAAGGCCACATGTGGGAGAGACACCAGGTTACAGGGCAGACAGAGGGG
Downstream sequence
CACAAGCCAGTCCTACAGCAAGCCCAGAGACATGGCGGAGAGGTGGCGGCCCCGGGGATCTGAGAAGGGAGAGGGGTTCCCACCCCACGCAGGGTGGCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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