Basic Information
VIS ID
TVIS44023867
Fusion event
HTLV-1-CA10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
49760074/51682714 (Hg38)
End
49760074/51682714 (Hg38)
Orient
-
Location type
Intronic
Target gene
CA10
miRNAs that regulate target gene
hsa-mir-148b-3p
Nearest miRNA
hsa-mir-10226/Upstream/913984; hsa-mir-1250/Downstream/5208556;
Nearest TSS
ENST00000595228/Upstream/243061; ENST00000572848/Downstream/65074;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/421492, chr17-CpG: 89/Downstream/475101
Upstream sequence
AGCGACCATTTACTGCCACCACCCAAAGGCTTCATCCCATTTACCCCACCTACCCATGGCCATATATTCTATGAGAACATTCTGAAATTTTGTATATACA
Downstream sequence
TTGGAAACAGAAGCTTGTCTCCTTACCATTAATAACCAAATGTAAGGAAATGGAAAGACGGAACACGCCCTGATAAACGTGGGGCAAAGAAGGGAAACCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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