Basic Information
VIS ID
TVIS44023874
Fusion event
HTLV-1-EPX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q22
Reference genome
GRCh37/hg19
Start
56271401/58194040 (Hg38)
End
56271401/58194040 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA17B
Target gene
EPX
miRNAs that regulate target gene
hsa-mir-1236-3p ; hsa-mir-6749-3p ; hsa-mir-6826-3p ; hsa-mir-6734-3p ; hsa-mir-6780b-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-6818-3p
Nearest miRNA
hsa-mir-10226/Upstream/1302685; hsa-mir-1250/Downstream/137192;
Nearest TSS
ENST00000595228/Upstream/1303; ENST00000582684/Downstream/8963;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/36574, chr17-CpG: 17/Downstream/2991
Upstream sequence
CCTATCCCACCCATGGCTGCAGGAGGAGACCCTTGCTAGGGGCCTCCAACCAGGCTCTGGCTCGCTGGCTGCCCGCCGAGTATGAGGATGGGCTGTCGCT
Downstream sequence
CCCCTTCGGCTGGACCCCCAGCAGGAGGCGCAATGGCTTCCTTCTCCCTCTTGTGAGTTGGGGCTGAGGGTTTGGGAGGTTGCTTGATCTCTTAAAtgcg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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