Basic Information
VIS ID
TVIS44023879
Fusion event
HTLV-1-MAP3K3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
61766759/63689399 (Hg38)
End
61766759/63689399 (Hg38)
Orient
-
Location type
Intronic
Target gene
MAP3K3
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-9-5p ; hsa-mir-132-3p ; hsa-mir-124-3p ; hsa-mir-193b-3p ; hsa-mir-181a-5p ; hsa-mir-188-5p ; hsa-mir-19a-5p ; hsa-mir-19b-1-5p ; hsa-mir-19b-2-5p ; hsa-mir-96-5p ; hsa-mir-1271-5p ; hsa-mir-1178-5p ; hsa-mir-1182 ; hsa-mir-4328 ; hsa-mir-3613-3p ; hsa-mir-6753-3p ; hsa-mir-6885-3p ; hsa-mir-7107-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-181d-5p ; hsa-mir-519d-3p ; hsa-mir-2052 ; hsa-mir-3140-3p ; hsa-mir-140-3p ; hsa-mir-182-5p ; hsa-mir-183-5p ; hsa-mir-193a-3p ; hsa-mir-328-5p ; hsa-mir-4459 ; hsa-mir-4754 ; hsa-mir-4779 ; hsa-mir-6774-5p ; hsa-mir-6804-5p ; hsa-mir-759 ; hsa-mir-3119 ; hsa-mir-892b
Nearest miRNA
hsa-mir-10226/Upstream/745087; hsa-mir-1250/Downstream/811375;
Nearest TSS
ENST00000595228/Upstream/657; ENST00000581732/Downstream/931;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/66031, chr17-CpG: 221/Downstream/10131
Upstream sequence
AGACTACTTCCTAATTTCTGCTTTTGTCCTGATTCTTGGAGTGCTTGGGACAGCAGCCTCTGTGGAATGAGTCAGGTGGGAGTGCGGACGGGATGGGCTG
Downstream sequence
GAGCTGGTATTATCTATCACTTCTGGCTGAGACCTGGTTTGTATATTCCGCCTTGTAGCCCGGGGTGTCTCAGACCTGGTTTGTACGTTCCGCCTCGTAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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