Basic Information
VIS ID
TVIS44023887
Fusion event
HTLV-1-UNC13D integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
73826034/75829953 (Hg38)
End
73826034/75829953 (Hg38)
Orient
+
Location type
Intronic
Target gene
UNC13D
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1-3p ; hsa-let-7b-5p ; hsa-mir-320a ; hsa-mir-3180-5p ; hsa-mir-7150 ; hsa-mir-6867-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-6826-3p ; hsa-mir-4736 ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-6832-3p ; hsa-mir-6892-3p ; hsa-mir-6795-3p ; hsa-mir-6887-3p ; hsa-mir-665
Nearest miRNA
hsa-mir-10226/Upstream/45346; hsa-mir-1250/Downstream/268066;
Nearest TSS
ENST00000595228/Upstream/9898; ENST00000586076/Downstream/194;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/44726, chr17-CpG: 78/Downstream/25226
Upstream sequence
aggtgtgagccaccacatccagcTGCAAACTCTTGTCCCAGATGCCCCATCCCTTGGGCCCAAATGTGGCCATCTCAGGGGAGCCCCTTGGCCCCAGCCA
Downstream sequence
GGAGGAGCAGGCCTGAGGGAGCCCAGTGGGGAGAGATGAGGGGAGGGACTGGGAGAAGAACGGGACCCACTCACAATTCAAAGGTCTCATCAAACAATGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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