Basic Information
VIS ID
TVIS44023893
Fusion event
HTLV-1-TIMP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
76919770/78923688 (Hg38)
End
76919770/78923688 (Hg38)
Orient
+
Location type
Intronic
Target gene
TIMP2
miRNAs that regulate target gene
hsa-mir-519d-3p ; hsa-mir-519c-3p ; hsa-mir-200c-3p ; hsa-mir-106a-5p ; hsa-mir-429 ; hsa-mir-20a-5p ; hsa-mir-301a-3p
Nearest miRNA
hsa-mir-10226/Upstream/1526634; hsa-mir-1250/Downstream/783488;
Nearest TSS
ENST00000595228/Upstream/1287; ENST00000582295/Downstream/1699;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/22472, chr17-CpG: 118/Downstream/952
Upstream sequence
TCAAAGGAACCTCTCCTTCACCCACAAATCTTGCTGAGCACCAAGGCTAAACTGGAGAAAAGACCTCATTTCCCCCAAACTGGGTTTTGTGGAAACTGAC
Downstream sequence
ACAGGCACACACCAAGCCTTCCGCCCAGGTGGCCTGAGCCACCTGAGACCTGTGATCTCAATAGATTGGTGCAACTGAAAACTTCCCCAGCTGGGCACGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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