Basic Information
VIS ID
TVIS44023897
Fusion event
HTLV-1-RPTOR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
78932998/80959198 (Hg38)
End
78932998/80959198 (Hg38)
Orient
+
Location type
Intronic
Target gene
RPTOR
miRNAs that regulate target gene
hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-155-5p
Nearest miRNA
hsa-mir-10226/Upstream/539705; hsa-mir-1250/Downstream/166078;
Nearest TSS
ENST00000595228/Upstream/10648; ENST00000572778/Downstream/2515;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/10765, chr17-CpG: 23/Downstream/2045
Upstream sequence
TGGTTGCTCTGGGCAGCAGCAGCCCGAGAACCTGGCCCAGGCCTTCCCGTGTGGGCAGCCTCCCCTCTGACGTGACCGTGGATCCCTCGAGGCACCAGCA
Downstream sequence
GCTTTCATGGCACCTTCTTTGGGGTGGGGGGGTCTTGCACCTGTCTGGAGCTGTGGCTCCACACGAGACGTAGCCCTCAGGGCACAGCGTGGACACCCTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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