Basic Information
VIS ID
TVIS44023900
Fusion event
HTLV-1-CCDC57 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
80142916/82185040 (Hg38)
End
80142916/82185040 (Hg38)
Orient
-
Location type
Intronic
Target gene
CCDC57
miRNAs that regulate target gene
hsa-mir-92a-3p
Nearest miRNA
hsa-mir-10226/Upstream/491171; hsa-mir-4525/Downstream/51628;
Nearest TSS
ENST00000595228/Upstream/9376; ENST00000581303/Downstream/132;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/57583, chr17-CpG: 119/Downstream/27406
Upstream sequence
TGAAGAAACAGACTCACCAACGGCCTCTGGTGCTCTGGGAAGCAGCTTTATCCCTGGACCATGAGCCACCTAATTATGAGGGCCAGCCCCACTCCCAGCA
Downstream sequence
TCAGGATGGTGATGTGACTCTGCCTGGGGCCTCCTGGACAGTCTCCCCTGATGCACAGTCTCAGGTGTAGATCAATGGGCACGGCTGCTGAGCCCTCACT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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