Basic Information
VIS ID
TVIS44023916
Fusion event
HTLV-1-ZNF521 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
22760606/25180642 (Hg38)
End
22760606/25180642 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF521
miRNAs that regulate target gene
hsa-mir-19b-3p
Nearest miRNA
hsa-mir-1-2/Upstream/858896; hsa-mir-122/Downstream/1410825;
Nearest TSS
ENST00000575820/Upstream/125042; ENST00000580645/Downstream/44147;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/753599, chr18-CpG: 113/Downstream/168573
Upstream sequence
TGCCTCAAGGTAAAGAGGATGGCATCTATCATAAGTGCAGAGAACGTCTGAAGGATTTAGAAGCAATCTTTTCATAATGCTTCTTTGGGTGAGGAAGTGG
Downstream sequence
AGTTATGAGTTACTCAAAATTCATAAAGATTATTAAGTTTACATCCTTACAGAAGATCTGCTGCTACTCTATTTCTCCACCATACTGCCAGCATTCCAGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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