Basic Information
VIS ID
TVIS44023925
Fusion event
HTLV-1-B4GALT6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
29252199/31672236 (Hg38)
End
29252199/31672236 (Hg38)
Orient
-
Location type
Intronic
Target gene
B4GALT6
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-190a-3p ; hsa-mir-3941 ; hsa-mir-4789-3p ; hsa-mir-5011-5p ; hsa-mir-205-5p ; hsa-mir-6868-3p ; hsa-mir-9-3p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-4789-5p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485
Nearest miRNA
hsa-mir-1-2/Upstream/1373276; hsa-mir-122/Downstream/3919501;
Nearest TSS
ENST00000575820/Upstream/13772; ENST00000565978/Downstream/12268;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/173673, chr18-CpG: 145/Downstream/12473
Upstream sequence
TCTAGAACTGTTTCCTGGGCTTTGCAGGACACCAACGCAGCATCCCTGTGATCCTGATATCTCTGTTCCTAGCTGCTATGACATGCTGCCACAGTTCCCA
Downstream sequence
GGTCTCTTAACAAAAGTCTAGTGAATAAATGATTTTGAGAGGGAGATGATGATCTTGGTCAGGCAATCTGGGATGCAGTTATAAATGTAGGACTGAAGCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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