Basic Information
VIS ID
TVIS44023928
Fusion event
HTLV-1-ASXL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
31279100/33699136 (Hg38)
End
31279100/33699136 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA18A
Target gene
ASXL3
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-26b-5p ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-4533 ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6783-5p ; hsa-mir-4779 ; hsa-mir-6510-5p ; hsa-mir-3120-3p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-1305 ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-498 ; hsa-mir-4465 ; hsa-mir-26a-5p ; hsa-mir-6715b-3p ; hsa-mir-1297 ; hsa-mir-676-5p ; hsa-mir-7844-5p ; hsa-mir-708-3p
Nearest miRNA
hsa-mir-1-2/Upstream/3400176; hsa-mir-122/Downstream/1892601;
Nearest TSS
ENST00000575820/Upstream/93495; ENST00000587528/Downstream/324503;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/120113, chr18-CpG: 45/Downstream/459947
Upstream sequence
agaaggcaggggagggtaacagtatatagaaatgctacaaaatatagtctaagatatccacttttcaaaagagagacacagagagggagagatacatata
Downstream sequence
taggccaagaaataagaaagaatgactcaagagtctagaaaaccggcaagaaaatcttctatgaaatgctctgatgttagattgaacagaaaaaggcttg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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