Basic Information
VIS ID
TVIS44023950
Fusion event
HTLV-1-RELCH integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
59958646/62291413 (Hg38)
End
59958646/62291413 (Hg38)
Orient
+
Location type
Intronic
Target gene
RELCH
miRNAs that regulate target gene
hsa-mir-378a-3p ; hsa-mir-92a-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-651-5p ; hsa-mir-655-5p ; hsa-mir-1258 ; hsa-mir-3163 ; hsa-mir-4443 ; hsa-mir-3689d ; hsa-mir-6515-5p ; hsa-mir-6851-5p ; hsa-mir-374a-5p ; hsa-mir-374b-5p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-6131 ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-4635 ; hsa-mir-3663-5p ; hsa-mir-6513-3p ; hsa-mir-888-3p ; hsa-mir-606 ; hsa-mir-4696 ; hsa-mir-5700 ; hsa-mir-4282 ; hsa-mir-9-5p ; hsa-mir-4772-3p ; hsa-mir-7113-3p ; hsa-mir-1304-3p ; hsa-mir-6742-3p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-4308 ; hsa-mir-6777-3p ; hsa-mir-6890-3p ; hsa-mir-23b-5p ; hsa-mir-23a-5p
Nearest miRNA
hsa-mir-1-2/Upstream/3840255; hsa-mir-5011/Downstream/4790171;
Nearest TSS
ENST00000575820/Upstream/9093; ENST00000592013/Downstream/9585;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/103394, chr18-CpG: 131/Downstream/33423
Upstream sequence
gaataccactgacataaatagctttgtgtgaataaacacaattgactcctgataaataacttactctgcaaatgaggattcatgcttgaggggagcctgt
Downstream sequence
ttaccctgagtgatcactatgccataggtatGATATAAGAAGGCTTCTCTTTTATATGTAGTAACTCGGTTGTTCTGTTGGACATACCAATTTGGTTTTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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