Basic Information
VIS ID
TVIS44023964
Fusion event
HTLV-1-NFATC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q23
Reference genome
GRCh37/hg19
Start
77244726/79484726 (Hg38)
End
77244726/79484726 (Hg38)
Orient
+
Location type
Intronic
Target gene
NFATC1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-let-7b-5p ; hsa-mir-145-5p ; hsa-mir-4755-5p ; hsa-mir-5006-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-324-5p ; hsa-mir-3124-3p ; hsa-mir-4671-5p ; hsa-mir-6832-3p ; hsa-mir-143-3p
Nearest miRNA
hsa-mir-1-2/Upstream/6631344;
Nearest TSS
ENST00000575820/Upstream/13786; ENST00000590861/Downstream/8670;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/1090, chr18-CpG: 124/Downstream/1630
Upstream sequence
GACTTGAAAAGTCAGCACAAAAGCAACAAAATGCAGCAACTCCACTCGGAATCCCTGGGTGGAAAGCTCTGGTTGACTTCCTGCGGACTCAGGCTGGTGA
Downstream sequence
GATCCTACAGCTGGGAACGGCCCATATGGGTCAGTCCCTGTGATGCCTCCAGTGTGGCGGGAAGGTGGCTTGGCCACCATGGATGACTCGCGCCTGCCTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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