Basic Information
VIS ID
TVIS44023987
Fusion event
HTLV-1-RPSAP58 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p12
Reference genome
GRCh37/hg19
Start
23947214/23764412 (Hg38)
End
23947214/23764412 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
RPSAP58
miRNAs that regulate target gene
hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-3163 ; hsa-mir-411-5p ; hsa-mir-3121-3p ; hsa-mir-574-5p ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-6867-5p ; hsa-mir-4711-3p ; hsa-mir-342-3p ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-4738-3p
Nearest miRNA
hsa-mir-10395/Upstream/3365058; hsa-let-7e/Downstream/11358288;
Nearest TSS
ENST00000633603/Upstream/5521; ENST00000531821/Downstream/110289;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/1086, chr19-CpG: 32/Downstream/207243
Upstream sequence
TACATTCTCAAATGTAGGAAATGAGGACAAACAACTTCCTCTCTCCAATTTACAACACTATCAACTATTTGTCCTTTATTGTGCATTTCAGACACAGTGT
Downstream sequence
TTTAATTGTTAATCATGTTTTTACACTGCAGTGGATGGCAGGTTTTTAAAGATTTGTTTTCTGTTTGTAAACACttttttattggagacagagtttcatt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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