Basic Information
VIS ID
TVIS44023988
Fusion event
HTLV-1-THOP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
2796764/2796766 (Hg38)
End
2796764/2796766 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
THOP1
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-24-3p ; hsa-mir-19b-3p ; hsa-mir-935 ; hsa-mir-425-5p ; hsa-mir-615-3p ; hsa-mir-505-3p ; hsa-mir-484 ; hsa-mir-222-3p
Nearest miRNA
hsa-mir-1227/Upstream/165973; hsa-let-7e/Downstream/1164648;
Nearest TSS
ENST00000633603/Upstream/759; ENST00000592639/Downstream/9251;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/6047, chr19-CpG: 36/Downstream/2729
Upstream sequence
AGTACTGGGTGCGGGGAGTGCTGGGCGTGGCCAGTGGAGCTTCTGTGGCCCCCTGCCCCTGCCTCCTCGGGAGCGTCCCCCCTTCAGGGCTGACCCCCGG
Downstream sequence
CCTGATGTCCATCTTTCTTCTGCCTGAGGACCTGAACTCTGGCAAGGCAGGTCCACACAGACATGGGGCGCAGAGGCTCGGTAACGAGGGGAGCCCCTCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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