Basic Information
VIS ID
TVIS44024003
Fusion event
HTLV-1-CAPN12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
39224264/38733624 (Hg38)
End
39224264/38733624 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
CAPN12
Nearest miRNA
hsa-mir-10395/Upstream/3387997; hsa-let-7e/Downstream/675999;
Nearest TSS
ENST00000633603/Upstream/5479; ENST00000602255/Downstream/1781;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/6407, chr19-CpG: 86/Downstream/2001
Upstream sequence
CCTTATTTGGCCTCTTTCAGGGTCACCCAACCCCTGCCAGGGACTGGCAACAAGCTAAGGTGTGGGCCTGTGGATGGCCACAGTGCAGACGGCCACAGCT
Downstream sequence
GAGCAGGGGGACTTGGAGACAATGGGATGGGAGAGAACAGGTCCTGTCCCCACGACCACCCCAGGACCCTGTCCACACCTGCTGCATTCAGTGCCAGCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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