Basic Information
VIS ID
TVIS44024008
Fusion event
HTLV-1-NOVA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
46475690/45972432 (Hg38)
End
46475690/45972432 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
NOVA2
miRNAs that regulate target gene
hsa-mir-7111-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-766-5p ; hsa-mir-4533 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-4510 ; hsa-mir-6127 ; hsa-mir-4419a ; hsa-mir-4277 ; hsa-mir-584-3p ; hsa-mir-4779 ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-223-3p ; hsa-mir-4446-5p ; hsa-mir-6809-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-4715-3p ; hsa-mir-4753-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-7113-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-10b-3p ; hsa-mir-500b-3p ; hsa-mir-4659b-3p ; hsa-mir-6875-3p ; hsa-mir-4659a-3p ; hsa-mir-4474-3p ; hsa-mir-3119 ; hsa-mir-627-3p ; hsa-mir-7114-5p ; hsa-mir-134-3p
Nearest miRNA
hsa-mir-10395/Upstream/297408; hsa-let-7e/Downstream/46500;
Nearest TSS
ENST00000633603/Upstream/9826; ENST00000594672/Downstream/877;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/19187, chr19-CpG: 19/Downstream/28418
Upstream sequence
CCTTTTCTTGTCACATCCCCTCACCAGCCACGCCTGTGTCACACACACTGGACCCCTTTCCTCTGATCTACACGGCCTCTTCTGGCTGACACCCAGAGCC
Downstream sequence
AGCCCATTCGGTGTCCCCCACACACCTCCTTGCATGTCACACACACCCTCTCATGTGTCACACTCTGCCACAGCCCCCTTGGGGGTGACAAGCACACACC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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