Basic Information
VIS ID
TVIS44024020
Fusion event
HTLV-1-POLRMT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
633031/633031 (Hg38)
End
633031/633031 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
POLRMT
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-30e-5p ; hsa-mir-30b-5p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-1302-11/Upstream/560921; hsa-let-7e/Downstream/171909;
Nearest TSS
ENST00000633603/Upstream/2862; ENST00000591390/Downstream/494;
Nearest CpG islands
chr19-CpG: 89/Target, None/Upstream, None/Downstream
Upstream sequence
GCGGTCCCTGCGGGAAAGACGAGAGCGGCTGAGCGGGGCCGGGCGTGTGGGCGGGGGCCTCCATAAAGGCAGAAGCCGAAGGGTCGAAGGGCAAAGGAGC
Downstream sequence
CCTAAACGCAGCGGAAACTCTCGGAGCACGGGCTTAAGTTGGAAAGAAACTAAGACAGCGAAGGTGGAAGGGCCCCGCCGCGGCGAACACGGGCGCGGAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate