Basic Information
VIS ID
TVIS44024026
Fusion event
HTLV-1-SLX4IP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
10428507/10447859 (Hg38)
End
10428507/10447859 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA20B
Target gene
SLX4IP
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-665 ; hsa-mir-7977 ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-4524a-3p ; hsa-mir-20b-3p ; hsa-mir-3137 ; hsa-mir-4329 ; hsa-mir-3664-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-5690 ; hsa-mir-4757-3p ; hsa-mir-2114-5p ; hsa-mir-5588-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-4695-5p ; hsa-mir-4524b-3p ; hsa-mir-510-5p ; hsa-mir-512-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/3076167; hsa-mir-1-1/Downstream/201777;
Nearest TSS
ENST00000382410/Upstream/12556; ENST00000488816/Downstream/150816;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/13514, chr20-CpG: 255/Downstream/224066
Upstream sequence
gcataaacatggctcactgcagccttgaactcctgggctcaagtgatcctcctgcctcagtttcccatgtagctgggaccacaggtgggggctccacacc
Downstream sequence
tggctgatttttttttttttttttttttagagatagggtctcactttgttgcctaggctggtctcgaactcctgggctcaagcagtcctcctgcctcagc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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