Basic Information
VIS ID
TVIS44024031
Fusion event
HTLV-1-MACROD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
14828326/14847680 (Hg38)
End
14828326/14847680 (Hg38)
Orient
-
Location type
Intronic
Target gene
MACROD2
miRNAs that regulate target gene
hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-4469 ; hsa-mir-486-5p ; hsa-mir-660-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-618 ; hsa-mir-502-5p ; hsa-mir-4786-3p ; hsa-mir-1915-5p ; hsa-mir-6841-3p ; hsa-mir-153-5p ; hsa-mir-6808-3p ; hsa-mir-7973 ; hsa-mir-486-3p ; hsa-mir-4252 ; hsa-mir-4725-5p ; hsa-mir-6852-5p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-504-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/4197985; hsa-mir-1-1/Downstream/3622935;
Nearest TSS
ENST00000382410/Upstream/324282; ENST00000486914/Downstream/81806;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/851258, chr20-CpG: 50/Downstream/1725511
Upstream sequence
ATGAGGCACACTTCAAAAAGTAGAATGATTAGCATTTCTTGGTAAGATGACAGTCCCCCCTTTTAAAAAAAAATTGTTCATTAGTTTTATCAATAGATTA
Downstream sequence
CATATCCAGATTTCAATTTTGAGTGCATACTTTTTGCTTATAATTATAATGTGAATTTAAATAGTTTTAGATTGTGCATTTAAAACAATTCTTCTGTCAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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