Basic Information
VIS ID
TVIS44024042
Fusion event
HTLV-1-MGME1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
17966143/17985500 (Hg38)
End
17966143/17985500 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA20A
Target gene
MGME1
miRNAs that regulate target gene
hsa-let-7b-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/7335805; hsa-mir-1-1/Downstream/485115;
Nearest TSS
ENST00000382410/Upstream/15443; ENST00000429853/Downstream/65239;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/16135, chr20-CpG: 167/Downstream/70720
Upstream sequence
caacaagagtgaaacaccatctcaaaataattaaagaagtttatacagtaaaaaagttacagtaagctaaagttaatgtattattgaagaaagaaaaacg
Downstream sequence
ttttttataaatttagtgtagcgtaagtgtacagtgtttataaagtctatagtagtatacagtaatgtcccaggccctcacattcactcaccgctcactc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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