Basic Information
VIS ID
TVIS44024044
Fusion event
HTLV-1-SLC24A3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
19475630/19494986 (Hg38)
End
19475630/19494986 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA20A
Target gene
SLC24A3
miRNAs that regulate target gene
hsa-let-7c-3p ; hsa-mir-3177-5p ; hsa-mir-4475 ; hsa-mir-4668-5p ; hsa-mir-511-3p ; hsa-mir-548aa ; hsa-mir-548ap-3p ; hsa-mir-548t-3p ; hsa-mir-5584-5p ; hsa-mir-624-3p ; hsa-mir-7845-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/1024295; hsa-mir-1-1/Downstream/6713200;
Nearest TSS
ENST00000382410/Upstream/210390; ENST00000432334/Downstream/262722;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/281728, chr20-CpG: 127/Downstream/262409
Upstream sequence
cccaagacagagattcttgtgcaagtcattcattgttggagagatctccagagaaaaggagtgagagaaacaggatcaggcaggaaaggaggcaacaaag
Downstream sequence
gagtggtgttggctgcagaccagcctcaggtggatcccaggagaccatggagtgtgaatggcaccacagagctgtcctgccttgaggcaggagctggcct
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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