Basic Information
VIS ID
TVIS44024047
Fusion event
HTLV-1-RIN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
19901174/19920530 (Hg38)
End
19901174/19920530 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA20A
Target gene
RIN2
miRNAs that regulate target gene
hsa-mir-429 ; hsa-mir-200a-3p ; hsa-mir-200c-3p ; hsa-mir-141-3p ; hsa-mir-200b-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/1449839; hsa-mir-1-1/Downstream/6287656;
Nearest TSS
ENST00000382410/Upstream/30964; ENST00000484638/Downstream/14595;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/161401, chr20-CpG: 37/Downstream/54362
Upstream sequence
AGAGGTCATGGAGTAATCTAAGGCAACACTGGACTCAGACAACTGATGCAATAGATCAAGGCCTCAGCAGGAGGACTGTTTCAAGATACAGCCACACACG
Downstream sequence
CTGCTTCCGTAGTTCACACATTGAACTGCAGATACTACACGCACCTTTTACAACTTATTTTTCTTTCTCTGTGAGCATGCGCCAAATTGAAGGTTATATC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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