Basic Information
VIS ID
TVIS44024096
Fusion event
HTLV-1-OPRL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
62723119/64091766 (Hg38)
End
62723119/64091766 (Hg38)
Orient
-
Location type
Intronic
Target gene
OPRL1
miRNAs that regulate target gene
hsa-mir-324-5p ; hsa-mir-6499-3p ; hsa-mir-202-3p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-6786-3p ; hsa-mir-7162-3p ; hsa-mir-544b ; hsa-mir-4319 ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-331-3p ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-6793-3p ; hsa-mir-6729-3p ; hsa-mir-6733-3p
Nearest miRNA
hsa-mir-1-1/Upstream/14756;
Nearest TSS
ENST00000382410/Upstream/6750; ENST00000644172/Downstream/10628;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/4103, chr20-CpG: 33/Downstream/6637
Upstream sequence
CCCCGTGTCTGTGTGTCCTTGTGTGTGTCTCTCTGTCCTGTGTCTCCAATCCTGTGTCTGTGAACCCGTGGGCATCTCTGTCCGTGTGTCCTGGCCTGTG
Downstream sequence
CGTGTGTGTCTGTCTGGGGTCTGTGGGTCTGAGCCTCCTTTTTCATCTCTGTGTGTCCTGGACTGTGTGTCTGTCCCCGTCCAGTGTGGGGCCGGCGCAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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