Basic Information
VIS ID
TVIS44024097
Fusion event
HTLV-1-PCMTD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
62901490/64270137 (Hg38)
End
62901490/64270137 (Hg38)
Orient
+
Location type
Intronic
Target gene
PCMTD2
miRNAs that regulate target gene
hsa-mir-142-3p ; hsa-mir-23b-3p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-365a-3p ; hsa-mir-365b-3p ; hsa-mir-4457 ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-6506-3p ; hsa-mir-935 ; hsa-mir-5094 ; hsa-mir-6505-5p ; hsa-mir-9-5p ; hsa-mir-548as-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac
Nearest miRNA
hsa-mir-1-1/Upstream/193127;
Nearest TSS
ENST00000382410/Upstream/4625; ENST00000266078/Downstream/1345;
Nearest CpG islands
chr20-CpG: 59/Target, None/Upstream, None/Downstream
Upstream sequence
TGTGAGTGCATGGCGTGGGGTCTTGTGAGTGCGGGCGTGCACGGTGTGGGGTCTTGAGTTCAGGCGTGCACGGTATGGGGTCGTGTGAGTGCATGGTGTG
Downstream sequence
GGGTCGTCAGTGCGGGCATGCACGTtgtggggtcgtgtgggtgtgcacggtgtggggtcgtgagtgcgggcgtgcgtggtgcggggtcatgtgagtgcac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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