Basic Information
VIS ID
TVIS44024125
Fusion event
HTLV-1-URB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.11
Reference genome
GRCh37/hg19
Start
33703618/32331309 (Hg38)
End
33703618/32331309 (Hg38)
Orient
-
Location type
Intronic
Target gene
URB1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-760 ; hsa-mir-744-5p ; hsa-mir-106b-3p
Nearest miRNA
hsa-let-7c/Upstream/1955931; hsa-mir-3197/Downstream/1219353;
Nearest TSS
ENST00000624081/Upstream/22572; ENST00000534991/Downstream/3025;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/52107, chr21-CpG: 71/Downstream/61395
Upstream sequence
GCTGGACCTAGGAAAACATGAGGAACTGCAACAGTTCTCCCTCTAGAATGAGGAAACTGTGGCCAGAGGTAGGGCAGGAAGTGCATTTTCCCTGTATACC
Downstream sequence
CTTCAGCACCTGCTGAATTTCAAACTGTGAATGTATTACCTAATGTTAAAAATTAATGAACTTagacttcccaattctggcaagatggagtagacatgct
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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