Basic Information
VIS ID
TVIS44024137
Fusion event
HTLV-1-PRDM15 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
43290840/41870731 (Hg38)
End
43290840/41870731 (Hg38)
Orient
+
Location type
Intronic
Target gene
PRDM15
miRNAs that regulate target gene
hsa-mir-587 ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-4529-5p ; hsa-mir-4635 ; hsa-mir-212-3p ; hsa-mir-132-3p
Nearest miRNA
hsa-let-7c/Upstream/123890; hsa-mir-5692b/Downstream/1080197;
Nearest TSS
ENST00000624081/Upstream/98; ENST00000412906/Downstream/8742;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/15927, chr21-CpG: 156/Downstream/7770
Nearest cancer related gene
PRDM15(OG, No orient, 0)
Upstream sequence
acacacacaggcacggcagaggccccgaaaagtccttcaacaaaaatctctgctgagatgtgttctgtccagcaggtgcccgaatttatttgggcaaaga
Downstream sequence
gcaccttttGCACACGCTGATGAACGTGCTCAAGAAGGATGGTCCACACTGCAGACTCCCGGGGTCAGCAAAGGGGCAGGGCCTGGCTTTGCTACAAGAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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