Basic Information
VIS ID
TVIS44024140
Fusion event
HTLV-1-AGPAT3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
45331650/43911769 (Hg38)
End
45331650/43911769 (Hg38)
Orient
+
Location type
Intronic
Target gene
AGPAT3
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-24-3p ; hsa-mir-18a-3p ; hsa-mir-149-5p ; hsa-mir-100-5p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-6744-3p ; hsa-mir-4757-5p
Nearest miRNA
hsa-let-7c/Upstream/301780; hsa-mir-6815/Downstream/1566497;
Nearest TSS
ENST00000624081/Upstream/7878; ENST00000498670/Downstream/4503;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/45751, chr21-CpG: 24/Downstream/31823
Upstream sequence
TGTGCTCTGGAACATCCCACACGGGGTTCCTCCCATTGGAACACAGGTAAAGGGCTCTATGCATGCACATTTCTGCGTGTTTTATTGACCGGGTCATCTG
Downstream sequence
TGTTCATTAGCTAGCAGCTCCCCTGCAGTCCTCTGAAGTGCAGGCCAGCAGAGACGGGGGCGGTGGCTTTCGTCTGACCATGCCTAGTCACGAGGCTGCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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