Basic Information
VIS ID
TVIS44024144
Fusion event
HTLV-1-COL18A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
46875658/45455744 (Hg38)
End
46875658/45455744 (Hg38)
Orient
+
Location type
Exonic
Target gene
COL18A1
miRNAs that regulate target gene
hsa-mir-877-3p ; hsa-mir-92a-3p ; hsa-mir-6749-5p ; hsa-mir-450a-1-3p ; hsa-mir-3977 ; hsa-mir-3157-5p ; hsa-mir-8059 ; hsa-mir-4471 ; hsa-mir-1292-5p ; hsa-mir-661 ; hsa-mir-27b-5p ; hsa-mir-7155-5p ; hsa-mir-6852-5p ; hsa-mir-4538 ; hsa-mir-4453 ; hsa-mir-1227-5p ; hsa-mir-1257 ; hsa-mir-125a-3p ; hsa-mir-3155a ; hsa-mir-3155b ; hsa-mir-3175 ; hsa-mir-3665 ; hsa-mir-4259 ; hsa-mir-4260 ; hsa-mir-4284 ; hsa-mir-4310 ; hsa-mir-4711-5p ; hsa-mir-4736 ; hsa-mir-484 ; hsa-mir-486-3p ; hsa-mir-513a-5p ; hsa-mir-513b-3p ; hsa-mir-5192 ; hsa-mir-571 ; hsa-mir-6721-5p ; hsa-mir-6731-5p ; hsa-mir-6798-5p ; hsa-mir-6815-3p ; hsa-mir-7157-5p ; hsa-mir-8085
Nearest miRNA
hsa-let-7c/Upstream/1845755; hsa-mir-6815/Downstream/22522;
Nearest TSS
ENST00000624081/Upstream/213; ENST00000459895/Downstream/34531;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/15030, chr21-CpG: 49/Downstream/510
Upstream sequence
AGCCATGCAGCTACCACGATCCCTGAGCCCCAGGGGCCCCTGCCTGTGCAGCCCACAGCAGATACCACCACACACGTGACCCCCCGGAATGGTTCCACAG
Downstream sequence
AGCCAGCGACAGCCCCTGGCAGCCCTGAGCCACCCTCAGAGCTGCTGGAAGATGGCCAGGACACCCCCACTTCTGCCGAGAGCCCGGACGCGCCAGAGGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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