Basic Information
VIS ID
TVIS44024149
Fusion event
HTLV-1-CECR2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
17959352/17480310 (Hg38)
End
17959352/17480310 (Hg38)
Orient
+
Location type
Intronic
Target gene
CECR2
miRNAs that regulate target gene
hsa-mir-1296-5p ; hsa-mir-484 ; hsa-mir-151a-3p ; hsa-mir-29b-3p ; hsa-mir-6880-5p ; hsa-mir-6745 ; hsa-mir-363-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-6081 ; hsa-mir-6716-5p ; hsa-mir-3665 ; hsa-mir-3160-3p ; hsa-mir-125a-3p ; hsa-mir-6782-5p ; hsa-mir-3936 ; hsa-mir-4271 ; hsa-mir-3978 ; hsa-mir-877-5p ; hsa-mir-766-5p ; hsa-mir-1253 ; hsa-mir-520g-5p ; hsa-mir-3614-5p ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-890 ; hsa-mir-4311 ; hsa-mir-520b ; hsa-mir-520c-3p ; hsa-mir-520d-3p ; hsa-mir-520a-3p ; hsa-mir-302a-3p ; hsa-mir-302b-3p ; hsa-mir-302c-3p ; hsa-mir-302d-3p ; hsa-mir-302e ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-520e
Nearest miRNA
hsa-let-7a-3/Downstream/283870;
Nearest TSS
ENST00000624155/Upstream/3217; ENST00000355219/Downstream/68689;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/61070, chr22-CpG: 17/Downstream/100864
Upstream sequence
TCTGCTTCAAGCTGTAttatccattgttaagtaacaaattaccctaaaacttagcaacttaaaaccacaaaaagtgtaatcttacagtttctgtgggtca
Downstream sequence
ggaacctggacaaaccactactggtgtgtttagctcgagttagcttacaggtctgtgatcaaggtaccagtgacagcagtcatcttgaaactTACTACTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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