Basic Information
VIS ID
TVIS44024151
Fusion event
HTLV-1-ATP6V1E1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
18077197/17594431 (Hg38)
End
18077197/17594431 (Hg38)
Orient
-
Location type
Intronic
Target gene
ATP6V1E1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-16-5p ; hsa-mir-423-5p ; hsa-mir-18a-3p ; hsa-mir-221-3p ; hsa-mir-1236-5p ; hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-3125 ; hsa-mir-3184-5p ; hsa-mir-34a-5p ; hsa-mir-34c-5p ; hsa-mir-3910 ; hsa-mir-3916 ; hsa-mir-3942-5p ; hsa-mir-429 ; hsa-mir-4423-3p ; hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-4688 ; hsa-mir-4703-5p ; hsa-mir-4708-3p ; hsa-mir-4709-3p ; hsa-mir-4765 ; hsa-mir-4797-5p ; hsa-mir-486-3p ; hsa-mir-542-3p ; hsa-mir-548v ; hsa-mir-6501-3p ; hsa-mir-6743-5p ; hsa-mir-6809-5p ; hsa-mir-6825-3p ; hsa-mir-6859-5p
Nearest miRNA
hsa-let-7a-3/Downstream/169749;
Nearest TSS
ENST00000624155/Upstream/5239; ENST00000464649/Downstream/861;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/13020, chr22-CpG: 40/Downstream/33935
Upstream sequence
TGACCCCAAATTCACCCTCATGTAAATGTTACCACCTCAGCAAATGCTACTACATGCCCAATTCTCATTCTTTTTGAGAAAATGTCCAAAACTGGAAAGA
Downstream sequence
CAGCAACAAATCCCAAATACCAGTGAATGGACACGTGTTCTCTGTCCCACTTCAAAGTAACAGCAGACCAACTACCAAGAAGTACCCCCACACTCACCTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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