Basic Information
VIS ID
TVIS44024154
Fusion event
HTLV-1-PI4KA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
21096172/20741884 (Hg38)
End
21096172/20741884 (Hg38)
Orient
-
Location type
Intronic
Target gene
PI4KA
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-93-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1286/Upstream/492673; hsa-let-7a-3/Downstream/292292;
Nearest TSS
ENST00000624155/Upstream/5018; ENST00000406799/Downstream/1033;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/37379, chr22-CpG: 106/Downstream/116538
Upstream sequence
CTAATCAGCTGAAACGTGAGTATAAACTTCCTTGTGGGCACCCCCTGCAGTAGCAACTCCAGAAATACGGATGCAGGGAAAGGGGGCTGATCCCAAGATT
Downstream sequence
AGGTCAAGAAAAACATTCCCGTGGACAAACACAACTGCTCCCAATCAAATTCAAAGTTAACAGGTGTTCAAAAAGCTGGATTTCCAATTTCAGTAGAGAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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