Basic Information
VIS ID
TVIS44024156
Fusion event
HTLV-1-SPECC1L-ADORA2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
24720894/24324926 (Hg38)
End
24720894/24324926 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
SPECC1L-ADORA2A
Nearest miRNA
hsa-mir-1286/Upstream/1438547; hsa-let-7a-3/Downstream/1130720;
Nearest TSS
ENST00000624155/Upstream/20530; ENST00000472799/Downstream/87234;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/53419, chr22-CpG: 131/Downstream/98643
Upstream sequence
ggtgacagagtgagactttatttcaaaacagaaaagaaaaaGTCACAGATTGATCCTGTGTCCATGGTAACTGCCTGGCAATATCAGCATGATTGATGGA
Downstream sequence
GATATAACCAGAGCGAGAATGGATTATTTTTTGTCAGAGAATAATGGGGTTCATAATCAATAATGGGACTCAAAAGTTATGAACCCATTATTAAATGAGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate