Basic Information
VIS ID
TVIS44024163
Fusion event
HTLV-1-ZMAT5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
30145013/29749024 (Hg38)
End
30145013/29749024 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22B
Target gene
ZMAT5
miRNAs that regulate target gene
hsa-mir-296-3p ; hsa-mir-484 ; hsa-mir-377-5p ; hsa-mir-6734-5p ; hsa-mir-7847-3p ; hsa-mir-6885-5p ; hsa-mir-6880-5p ; hsa-mir-328-5p ; hsa-mir-486-3p ; hsa-mir-3175 ; hsa-mir-8085 ; hsa-mir-6721-5p ; hsa-mir-6731-5p ; hsa-mir-4736 ; hsa-mir-6894-5p ; hsa-mir-765 ; hsa-mir-7154-3p ; hsa-mir-766-5p ; hsa-mir-5192 ; hsa-mir-3665 ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-4693-3p ; hsa-mir-558 ; hsa-mir-22-3p ; hsa-mir-5586-3p
Nearest miRNA
hsa-mir-1286/Upstream/1289076; hsa-let-7a-3/Downstream/258025;
Nearest TSS
ENST00000624155/Upstream/28940; ENST00000401406/Downstream/17937;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/19348, chr22-CpG: 22/Downstream/17823
Upstream sequence
tctcagcctctcaaagtgctgggattacaggcatgagccactgtgcctggctgctgtttggtagtttttAAAGTCTATCAGGTGATTCTAACATGTAAGT
Downstream sequence
AGGCTGAACTGCCACCTTATACCCTGTGGctggcctcccttgtctcctaccacatagggttttatttttttgagacagagtctcgctctgtcacccaggg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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