Basic Information
VIS ID
TVIS44024171
Fusion event
HTLV-1-LARGE1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
33819659/33423673 (Hg38)
End
33819659/33423673 (Hg38)
Orient
+
Location type
Intronic
Target gene
LARGE1
miRNAs that regulate target gene
hsa-mir-18a-5p
Nearest miRNA
hsa-mir-1286/Upstream/1802142; hsa-let-7a-3/Downstream/12909;
Nearest TSS
ENST00000624155/Upstream/39446; ENST00000610170/Downstream/141346;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/365205, chr22-CpG: 20/Downstream/226695
Upstream sequence
ggaggctgaggcgcgggaatggcttgaaccccggagacgaaggttgcagtgagcagagattgcaccactgccctccagcctgggctctgctgtgagattc
Downstream sequence
tgtctcaaaaaaaaaaaaaaaaaattacacttgtaggcaatataatatagatgtaatccttgaatttcattccaggattataaaagaggcattcaaaaca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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