Basic Information
VIS ID
TVIS44024187
Fusion event
HTLV-1-CBX7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
39537824/39141819 (Hg38)
End
39537824/39141819 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
CBX7
miRNAs that regulate target gene
hsa-mir-421 ; hsa-mir-181b-5p ; hsa-mir-766-3p ; hsa-mir-6818-3p ; hsa-mir-4515 ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-3169 ; hsa-mir-4700-3p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-18a-3p ; hsa-mir-9-5p ; hsa-mir-9-3p
Nearest miRNA
hsa-mir-1286/Upstream/1152966; hsa-let-7a-3/Downstream/1672064;
Nearest TSS
ENST00000624155/Upstream/7040; ENST00000641466/Downstream/8013;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/214296, chr22-CpG: 107/Downstream/3198
Nearest cancer related gene
CBX7(OG, No orient, 0)
Upstream sequence
gcctgggtgacagagtaagactctaaaaaaaaaaaaaaaaGGTCAGAGCCATCGCTTCTACTGGGCAGGTGCACCAGCAGAGGCCACTGCTGCTGACCCA
Downstream sequence
GTGCCCACTGCAAGTGTGCCTTCACCCTGTCCTGGTAAGGTGTCATTGTCACCTACTTCAAGGACAGACCCAGCCTGGGCCTCCTGAGGGCTCCAGCAAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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