Basic Information
VIS ID
TVIS44024189
Fusion event
HTLV-1-CCDC134 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
42214975/41818971 (Hg38)
End
42214975/41818971 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
CCDC134
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-let-7b-5p ; hsa-mir-6862-3p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-4267 ; hsa-mir-500b-3p ; hsa-mir-3943 ; hsa-mir-6875-3p ; hsa-mir-6749-3p ; hsa-mir-4778-3p ; hsa-mir-877-3p ; hsa-mir-1306-5p ; hsa-mir-1228-3p
Nearest miRNA
hsa-mir-1281/Upstream/565921; hsa-let-7a-3/Downstream/81973;
Nearest TSS
ENST00000624155/Upstream/18292; ENST00000464119/Downstream/14108;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/18014, chr22-CpG: 157/Downstream/13532
Upstream sequence
GAGATGCTTTATTGCTGTGATGCCAGTTCTTCTTGCTATGCAGGTCATAGATGCCTCACTTAAACGCAGGAGGAGGGTGACAGCATAGGCCACAGAGAGA
Downstream sequence
ATGGGTGCCAGGATAAGTTGAGTCCAGCTTTATCATAACGTATTCTACTTGGACATAACCACAGCAGCAACATACTTTCCTTACATGCTGGATGGGGACA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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