Basic Information
VIS ID
TVIS44024191
Fusion event
HTLV-1-A4GALT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
43098749/42702743 (Hg38)
End
43098749/42702743 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
A4GALT
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-483-3p ; hsa-mir-4314 ; hsa-mir-4279 ; hsa-mir-7111-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-3192-5p ; hsa-mir-4646-5p ; hsa-mir-204-3p ; hsa-mir-330-5p ; hsa-mir-326 ; hsa-mir-6817-3p ; hsa-mir-6845-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-5193
Nearest miRNA
hsa-mir-1281/Upstream/779446; hsa-let-7a-3/Downstream/2498211;
Nearest TSS
ENST00000624155/Upstream/7110; ENST00000443063/Downstream/18076;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/9081, chr22-CpG: 107/Downstream/17402
Upstream sequence
ACTCTTTACCCCCAACTGGCATGGGAGCCCCCTTGCCAGGAAGAGGACACCTGGACTCACTGGAACTGGGTGGTTTTGGGGAGGGGACGTAGTGGGAGAC
Downstream sequence
AAAGGGTCCGGAGCCTTCGTGCAGATAAGGTGGAACGCCCACCGGGTTCCTTCACTTGCCGAGGACGCACCTGGTGGAGTCAGGCGGTCCTGGCCCAAAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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